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职场小菜鸟必看的“升迁大法”02248
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官方公共微信　据《ScienceNOW》报道， 一项刊登在《细胞》(Cell)杂志上的最新研究表明，一个增加罹患睾丸癌的基因变异可能深受进化影响，因为它有助于保护那些白皙的人免受阳光紫外线 的伤害。这一发现可能是为什么白人比黑人对这种类型的更敏感的原因所在。这也有助于解释为什么睾丸癌是容易治愈的。
　　来自牛津大学路德维希癌症研究所等机构的科学家们在研究遗传基因对于罹患癌症的风险到底有多大影响时，对 p53 基因发生了兴趣。
　　根据一项最新研究，一个增加罹患睾丸癌的基因变异可能深受进化影响，因为它有助于保护那些皮肤白皙的人免受阳光紫外线的伤害。这一发现可能是为什么白人比黑人对这种类型的癌症更敏感的原因所在。这也有助于解释为什么睾丸癌是容易治愈的。
　　英国牛津大学路德维希癌症研究所分子生物学家Gareth
Bond和同事在研究遗传基因对于罹患癌症的风险到底有多大影响时，对p53基因发生了兴趣，这种基因的突变出现在超过一半的癌症患者身上。这种基因所产 生的蛋白质对癌细胞起到关键防御作用&&这种蛋白在其他许多基因中发挥作用，可以防止许多类型的压力，其中就包括DNA损伤和缺氧。它也能帮助癌症，迫使严重受损的细胞自行消灭。　p53的突变，或在起作用的其他基因上的活动，有效地防止了这一指令被接收，同时又能使受损的细胞继续繁殖，继而形成肿瘤。
　　那么又是什么原因导致了这种突变的产生呢?进化分析显示：这种基因变异已经变得非常普遍，在人类从非洲大陆向北迁移的过程中，这种变异出现在80%的欧洲白种人身上，相比只有24%的非洲人后裔体内发现了这种变异。或许并非巧合的是，在白人身上睾丸癌的发病几率是黑人的4&&5倍。
　　&由于早期从非洲向北迁移的人们，逐渐失去了可以让其在昏暗地带中能够保留更多维生素D的皮肤色素沉积，而恰恰是那些色素沉积能更好地修复紫外 线损伤。&研究人员称。Bond补充说：&对于我们的祖先而言，防止晒伤对于生存下去是至关重要的。例如，一次严重的烧伤可以导致感染的发生，而我们的祖 先是没有抗生素可用的。
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