It appears Mr. Stone doesn’t even know what a corresponding author is – Respectful Insolence
Remember my ? Remember how I predicted that the knives would come out from anti-vaccine loons? My original prediction was that Mark “Not a Doctor Not a Scientist” Blaxill would pull one of his usual brain dead attacks on genetic studies, such as his ” immaculate mutations” gambit.
I guessed wrong, apparently. It wasn’t Mark Blaxill who went on the attack first. Although Blaxill hadn’t tried his hand at a pseudoscientific deconstruction of this study as of Sunday afternoon, John Stone over at the anti-vaccine propaganda blog Age of Autism has already pulled this gambit. In a post epitomizing the arrogance of ignorance entitled , Stone lays this brain-meltingly stupid charge of a conflict of interest on the corresponding author of the Pinto et al study::
Prof Stephen Scherer who is the senior author of the autism gene study launched in Nature last week holds the ‘GlaxoSmithKline-CIHR Pathfinder Chair in Genetics and Genomics at the Hospital for Sick Children and University of Toronto.
The title used to be ‘GlaxoSmithKline-CIHR Endowed Chair”, GSK being one of the defendant companies in the UK MMR litigation
What’s so hilarious about this little paragraph is that Stone is clearly completely ignorant of just what an endowed chair is and because of that he’s just completely humiliated himself by laying down a swath of burning stupid that has consumed everything in its path.
Basically, to create an endowed chair, a company or wealthy donor gives a university a lot of money, and the university sets up the endowed chair using that money. The interest and dividends from the fund used to set up the chair are put at the disposal of the holder of the chair to do research and scholarship as he or she sees fit. The reason such chairs are desirable is because an endowed chair gives a researcher a reliable supply of funding without the need to write grant proposals or a department chair a source of funds for various projects that doesn’t have to come out of the departmental budget. It often allows a researcher to do more exploratory work or a department chair to engage in various research and educational activities by doling out funds from the chair to his faculty, for example, to support pilot projects by young faculty. Once an endowed chair is set up, the donor usually has no say over who gets the chair or how the money for the chair is spent. Claiming that Professor Scherer’s holding the GSK chair at his institution is an insurmountable COI that needed to be reported is, quite simply, ridiculous to anyone in academia who knows what an endowed chair is. Clearly, Mr. Stone does not, although one commenter going by the ‘nym of Werdna . It’s a rare thing indeed on AoA for a commenter to take a blogger to task like that, something that usually only happens when an AoA blogger makes a mistake too egregious even for some of the less nutty AoA readers.
Equally ridiculous is Mr. Stone’s lack of understanding of what a corresponding or first author is on a biomedical research paper:
While Prof Scherer’s departmental colleague Dalila Pinto is listed as lead author of the paper Scherer is listed as ‘correspondence author’ and he identifies himself as ‘senior author’ in Kevin Leitch’s LeftBrain/RightBrain blog.
Here’s a hint for Mr. Stone. The lead author of the paper is an honor usually reserved for the person who had the most to do with designing and doing the research. Most of the time the first author is the person who actually wrote the manuscript. On the other hand, the corresponding author of a scientific paper (at least a biomedical paper) is usually the author listed last or near last. More importantly for Mr. Stone’s criticism, the corresponding author and the senior author are nearly always one in the same, namely the author in whose laboratory and using whose funding the research described in the paper was performed. That’s it. That’s all those terms mean. There’s no inconsistency there. The terms are interchangeable. Mr. Stone would do well to learn a little bit about what he speaks before embarrassing himself so.
I’d be happy to educate him.
June 14, 2010
“immaculate mutations”
Jesus Christ as a member of the X-Men?
Claiming that Professor Scherer’s holding the GSK chair at his institution is an insurmountable COI that needed to be reported is, quite simply, ridiculous to anyone in academia who knows what an endowed chair is.
Well, of course there’s a COI, since if there wasn’t a COI then Scherer would agree with the AoA crowd.
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请在这里输入关键词：
科目：高中英语
来源：启东中学作业本　高一英语(下)
　　When Laura reached school-going age the discussions about moving became more urgent (紧迫的). Her father did not want the children to go to school with the village children and for once her mother agreed with him. Not because, as he said, they ought to have a better education than they could get at Lark R but because she feared they would tear their clothes and catch cold and get dirty heads going a mile and a half to and from the school in the village. So empty cottages in the market town were examined and often it seemed that the next week or the next month they would be leaving Lark Rise for ever, but again each time something would happen to prevent the removal, and gradually a new idea came up. To gain time, their father would teach the two eldest children to read and write, so that, if asked by the School Attendance Office, their mother could say they were leaving the small village shortly, and in the meantime, were being taught at home.
　　So their father brought home two copies of Mavor's First Reader and taug but just as Laura was beginning on words of one syllable (音节), He was sent away to work on a distant job, only corning home at weekends. Laura, left at the c-a-t s-I-t-s on the m-a-t's stage, then had to carry her book round after her mother as she went about her housework, asking,“Please, Mother, what does h-o-u-s-a spell?”or“W-a-l-k, Mother, what is that?”
　　Often when her mother was too busy or too tired to attend to her, she would sit and fix her eyes on a page that might as well have been printed in Hebrew (希伯来语) for all she could make of it, frowning (锁眉) and studying the print as though she would make out the meaning by force of concentration (专注).
　　After weeks of this, there came a day when, quite suddenly, as it seemed to her, the printed characters took on a meaning. There were still many words, even in the first page of that simple book, she
but she could jump those and make sense of the whole.“I'm reading! I'm reading!” she cried aloud.“Oh, Mother! Oh, Edmund! I'm reading!”
1．Laura's father didn't want his children to go to school at Lark Rise because ________.
A．it was too far away
B．they couldn't learn enough
C．their hair would become dirty
D．they would ruin their clothes
2．The children's father decided to teach them to read and write so that they ________.
A．had an excuse not to have to move
B．had a reason for not attending school
C．could write to the School Attendance Office
D．would be educated before they left the village
3．The underlined part “left at the c-a-t s-I-t-s on the m-a-t's stage”means that ________.
A．Laura was working hard and learning quickly
B．her father had no time to teach her
C．her mother was too busy to attend to her
D．Laura knew little about how to read and write
4．From the passage we can infer that ________ made Laura stare at a page in her book.
A．her lack of concentration
B．her inability to understand
C．her need to understand Hebrew
D．her determination to understand
5．Laura finally discovered she could read when she ________.
A．understood the main idea
B．understood all the words in her book
C．recognized the printed characters
D．jumped the first pages of her book
科目：高中英语
来源：黄冈题库　练考新课堂　高二英语（下）
　　Former US. Vice President A1 Gore, who came close to winning the presidency two years ago, said he will not run in 2004, and probably will not have another opportunity to seek the White House.
　　Though Gore would have been a frightening Democratic(民主党的)main runner, his decision to give up the 2004 race probably helped his party' s chances in the general election against President George W. Bush, Democrats said.
　　Many did not want to see Bush－Gore Ⅱ.
　　“The last campaign was an extremely difficult one,” Gore told CBS TV show “60 Minutes”. on Sunday.
　　While saying he still had the energy and drive to run again, Gore recognized, “There are a lot of people within the Democratic Party who felt exhausted (by the 2000 race)… who felt like, OK, ‘I don't want to go through that again.’ And I'm frankly sensitive to that feeling.”
　　In nearly two dozen interviews after Gore announced his plans, Democrats dutifully claimed their party had lost a top candidate, but one after another, they praised Gore for taking an early exit from a primary race he could have won, sparing them a repeat.
　　Gore, 54, said he was making his decision “in the full understanding that it probably means that I will never have another opportunity to run for president.”
　　Party activists(激进主义分子)blamed Gore for losing despite a booming economy and eight years of a Democratic administration. Gore even lost his home state of T a victory there would have given him the White House.
1．Which of the following can be the best title for this passage?
A．Gore Was Criticized
B．Gore Decides Not to Fight Bush in 2004
C．Former US. Vice President Al Gore
D．Al Gore and Gorge Bush
2．Why do you think Gore has decides not to run in 2004 according to this passage?
A．Because he is quite old
B．Because many people are against him
C．Because he quite understands the feelings of a lot of Democratic members
D．Because he doesn't want to be President of US
3．What was Gore's feeling when he made his decision?
A．DelightB．Sad
C．RegretfulD．Calm
科目：高中英语
来源：2008年宁夏银川一中高三年级第三次模拟考试、英语试卷
　　In the world of fairy tales, great and powerful men are often helped to victory by the small and weak．But in the US it has happened for real．
　　Nine–year–old Noah McCullough from Texas, has taken on the role of speaking to the public in support of President George W．Bush’s social security reforms．
　　On February 25 he signed an agreement with the American Congress to work for the White House as a volunteer．“What I want to tell people about social security is not to be afraid of the new plan,”Noah said．“It may be a change, but it’s a good change．”
　　Besides this task, he already has a higher goal．He plans to run for the White House in 2032．So far, Noah seems to have a very bright future．
　　Despite his age, Noah already has his firm opinion on running the US．“I firmly believe that the combination of large business and small governments creates a peaceful and present society because industry can stimulate(刺激)economic growth,”he said．
　　Noah’s politics do not come from his parents．“He is very patriotic(爱国的)and very republican,”said Noah’s mother, Donna McCullough．“It’s the way he was born．”
　　Noah’s interest began after a mock(模拟)election in the kindergarten when he was five years old．Now he has read more than 3,000 books on presidential history．He can recite the names of all 43 American presidents．He can also describe the achievements and events that took place during a president’s term of office．
　　His unusual experiences in the presidential campaign last year made him a famous figure．He was a member of Bush’s presidential campaign team．He gave speeches at the Republican convention(大会)and followed Bush around on his tour of 27 states．President Bush thinks highly of the boy, saying that he is“the miracle kid of the White House”．
Noah McCullough worked for the White House ________．
to support George W．Bush in the presidential campaign
to be a volunteer in the presidential campaign
to show his gift in the presidential campaigns
to drill for his running for the White House in 2032
Which of the following statements is TRUE according to the passage?
Noah seems to have a very bright future because he supports Bush．
Noah is the youngest of the Americans who support Bush．
Noah has been to more than half of the states in the presidential campaign．
Noah was born with his parents’ dream of his becoming US President．
We can infer from the passage that ________．
Noah can surely succeed in the 2032 presidential campaign
Noah’s polities are deeply affected by his parents
Bush had known Noah well before the presidential campaign began
Noah would develop industry and reduce government officials if he were elected President of the USA
Which is the best title of the passage?
The Small and Weak Can Help the Big and Strong
Little Boy Helps President Bush
Beginning of Noah’s Political Life
The US Future President
科目：高中英语
来源：陕西省宝鸡市2009届高三教学质量检测(一)英语试题
　　I remembered the first day I saw her playing basketball．I watched in wonder as she ran circles around the other kids．The boys always tried to stop her but no one could, though she seemed so small．She would practice shooting over and over again, sometimes until dark．
　　One day I asked her why she practiced so much．Without a moment of hesitation she said, “I want to go to college．The only way I can go is to get a scholarship．I like basketball．I am going to play college basketball．I want to be the best．My Daddy told me if the dream is big enough, the facts don’t count．”Then she repeated the routine．Well, I had to give in to her – she was determined．I watched her through those junior high years and into high school．Every week, she led her school team to victory．One day in her senior year, I saw her sitting in the grass, head cradled in her arms．Quietly I walked to her and asked what was wrong．“Oh, noting,” came a soft reply．“I am just too short．”The coach told her that at 5.5 inches she would probably never get to play for a top ranked team, so she should stop dreaming about college．But her father said those coaches were wrong．They just did not understand the power of a dream．He told her that if she really wanted to play for a good college and wanted a scholarship, nothing could stop her except one thing – her own attitude．He told her again, “If the dream is big enough, the facts don’t count”．
　　The next years, as she and her team went to the Northern California Championship game, she was seen by a college recruiter．She was indeed offered a scholarship, a full ride, to a Division I, NCAA women’s basketball team．She was going to get the college education that she has dreamed of and worked toward for all those years．It’s true：If the dream is big enough, the facts don’t count．
How long has the girl probably been practicing basketball before she went to college?________．
At most 3 years
About 2 years
At least 6 years
Less than 4 years
The underlined word in the passage referred to ________．
the person who finds new people to work in a company or a job
the person w ho persuades others to do something
the coach of a sports team
the person who is in charge of admitting students into colleges
What is the best title of the passage?________．
A way to success
If the dream is big enough
Basket ball－A way to success
A determined girl
Which of the following can lead a person to the goal according to this passage?________．
A good attitude
A big dream, hard practices and opportunity
Hard practice
A big dream
科目：高中英语
来源：广东省广州六中学年高一上学期期末考试英语试题
　　Mathematical ability and musical ability may not seem on the surface to be connected, but people who have researched the subject and studied the brain say that they are．Three quarters of the bright but speech-delayed children in the group I studied had a close relative who was an engineer, mathematician or scientist, and four fifths had a close relative who played a musical instrument．The children themselves usually took readily to math and other analytical subjects and to music．
　　Black, white and Asian children in this group show the same patterns．However, it is clear that blacks have been greatly overrepresented(被过多的代表)in the development of American popular music and greatly underrepresented in such fields as mathematics, science and engineering．
　　If the abilities required in analytical fields and in music are so closely related, how can there be this great discrepancy?One reason is that the development of mathematical and other such abilities requires years of formal schooling, while certain musical talents can be developed with little or no formal training, as has happened with a number of well-known black musicians．
　　It is precisely in those kinds of music where one can acquire great skill without formal training that blacks have excelled(擅长)popular music rather than classical music, piano rather than violin, blues rather than opera．This is readily understandable, given that most blacks, for most of American history, have not had either the money or the leisure for long years of formal study in music．
　　Blacks have not merely held their own in American popular music．They have played a large role in the development of jazz, both traditional and modern．A long string of names comes to mind－W．C．Handy, Louis Armstrong, Charlie Parker…and so on．
　　None of these presupposes(假设，意味着)any special innate(先天的)ability of blacks in music．On the contrary, it is perfectly consistent(一致的)with blacks having no more such inborn ability than anyone else, but being limited to being able to express such ability in narrower channels than others who have had the money, the time and the formal education to spread out over a wider range of music, as well as into mathematics, science and engineering．
What is the main idea of the first paragraph?
Mathematical ability and musical ability are connected．
Mathematical ability has more to do with the brain than musical ability．
More people are good at music than math．
More research should be done into the relationship between mathematical ability and math ability．
The word“discrepancy”(Para．3)most probably means ________．
difference
excellence
inborn ability
What can be inferred about opera?
It requires formal training．
It is often enjoyed by those with strong analytical ability．
It is disliked by blacks．
It is more difficult to learn than classical music．
Which of the following statements is true according to the last paragraph?
Blacks have special innate ability in music．
Unlike others, blacks do not have innate ability in music．
Jazz is one of the narrow channels through which blacks express their ability in music．
Those who have money and time choose mathematics over music．
Which of the following questions does the passage mainly concern?
Are musical ability and mathematical ability connected?
Why have blacks been greatly overrepresented in the development of American popular music?
What kinds of music require formal training?
What are the contributions made by black musicians?
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