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授予学位：硕士
学位年度：2013
摘要:（该内容经过伪原创处理，请直接查看目录）目标不雅察高、低睾酮程度组青年男性在愉快、中性、恐怖三种情感面貌安慰下的年夜脑激活状况，商量内源性睾酮对恐怖情感面貌辨认影响的神经机制。 对象起源于某年夜学100名正常青年男性自愿者，依据睾酮程度，采取四分位法分组，随机抽取高下睾酮程度组各12名作为研讨对象。 办法令两组被试分离注目愉快、中性和恐怖情感面貌图片，同时采取3。0Tesla核磁共振扫描体系搜集被试的年夜脑激活旌旗灯号。应用SPM8软件剖析处置数据。 成果（1）两组被试注目愉快情感面貌图片惹起的正性格绪反响评分差别无统计学意义，而注目恐怖情感面貌图片惹起的负性格绪反响评分差别有统计学意义；（2）注目愉快情感面貌图片时，高睾酮程度组的均匀激活脑区有阁下两侧的颞上回和岛叶，左边枕叶楔前叶、旁中心小时、中心前回和角回，右边颞中回、海马旁回、后扣带回和扣带回。（3）注目愉快情感面貌图片时，低睾酮程度组的均匀激活脑区有左边顶叶楔前叶、额叶sub一gyral。（4）注目愉快情感面貌图片时，睾酮程度高组比低组增长的激活脑区有阁下两侧的顶叶楔前叶、额中回，左边顶下小叶、额上回、额下回、中心前回，右边中心后回、旁中心小叶、扣带回、海马旁回。（5）注目恐怖情感面貌图片时，高睾酮程度组的均匀激活脑区有阁下两侧的颞上回和岛叶，左边颞横回、丘脑、额下回、中心前回和中心后回，右边颞中回、海马旁回、扣带回和脑桥。（6）注目恐怖情感面貌图片时，低睾酮程度组的均匀激活脑区是左边顶叶楔前叶。（7）注目恐怖情感面貌图片时，睾酮程度高组比低组增长的激活脑区有左边额上回、额下回和顶下小叶，右边岛叶、扣带回、海马旁回、额中回和中心后回。（8）注目中性面貌图片时，高睾酮程度组的均匀激活脑区有阁下两侧的颞上回，左边扣带回、中心后回、旁中心小叶、额上回、中心前回、顶下小叶和顶叶楔前叶，右边颞中回、后扣带回和海马旁回。（9）注目中性面貌图片时，低睾酮程度组的均匀激活脑区是左边叶下外侧核。（10）注目中性面貌图片时，睾酮程度高组比低组增长的激活脑区有阁下两侧的中心后回和额中回，左边旁中心小叶、中心前回、颞上回和梭状回，右边顶叶楔前叶、额上回、扣带回和岛叶。（11）高睾酮程度组的睾酮程度与愉快情感面貌安慰下激活的左中心前回（r=0。719）、右扣带回（r=0。719）强度呈正相干，与恐怖情感面貌安慰下激活的左岛叶（r=0。638）、右颞中回（r=0。855）强度呈正相干。 结论 1。人类情感加工触及多个年夜脑皮层区域的神经激活，年夜脑对分歧效价情感的加工既有堆叠性，又有自力性。愉快（正性）情感面貌加工重要触及左半球，恐怖（负性）情感面貌加工阁下半球均介入。 2。高睾酮程度情感面貌加工触及更多脑区，低睾酮程度则相反。 3。睾酮程度与2个愉快脑区（左中心前回、右扣带回）、2个恐怖脑区（左岛叶、右颞中回）的激活强度呈正相干。
Abstract:Objective observation of high, low testosterone level group of young men in a pleasant, neutral, three emotional comfort terror face Nianye brain activation status, discuss the neural mechanism of effects of endogenous testosterone on terrorist emotional face recognition. Object originated from a university in 100 healthy young male volunteers, on the basis of testosterone level, take the four quartile grouping, randomly selected high testosterone level group each 12 as the research object. The way to make the two groups of participants, neutral and terror separation attention pleasant emotional landscape picture, at the same time take 3. 0Tesla nuclear magnetic resonance scanning system to collect subjects brain activation signal. Application of SPM8 software to analyze the data handling. Results (1) the positive character emotional response score between two groups subjects pleasant emotional landscape picture attention caused no statistically significant, negative emotional response is statistically significant character difference and attention of emotional face score Horror P (2) attention pleasant emotional landscape picture, high testosterone levels group uniform the activated brain areas are you on both sides of the superior temporal gyrus and insula lobe, left occipital lobe precuneus, paracentral hours, precentral gyrus and angular gyrus, right middle temporal gyrus, parahippocampal gyrus, and posterior cingulate gyrus cingulate gyrus. (3) the attention of happy emotion face picture, low testosterone level group uniform the activated brain areas are left parietal and precuneus, frontal sub gyral. (4) the attention of happy emotion face image, a high degree of testosterone group growth than the low group activated brain areas are you on both sides of the parietal and precuneus, middle frontal gyrus, left inferior parietal lobule, superior frontal gyrus, inferior frontal gyrus, precentral gyrus, right postcentral gyrus, paracentral lobule, cingulate gyrus, hippocampus gyrus. (5) attention terrorist emotional face image, high testosterone level group uniform the activated brain areas are you on both sides of the superior temporal gyrus and insula, left transverse temporal gyrus, thalamus, inferior frontal gyrus, precentral gyrus and postcentral gyrus, right middle temporal gyrus, parahippocampal gyrus, cingulate and pons. (6) the attention of emotional face Horror Picture, low testosterone level group uniformly activated brain areas is the left parietal and precuneus. (7) attention terrorist emotional face image, high level of testosterone group growth than the low group activated brain areas are left superior frontal gyrus, inferior frontal gyrus and inferior parietal lobule, right insula, cingulate gyrus, parahippocampal gyrus, middle frontal gyrus and the center back. (8) attention neutral face pictures, high testosterone level group uniform the activated brain areas are you on both sides of the superior temporal gyrus, left cingulate gyrus, paracentral lobule, postcentral gyrus, superior frontal gyrus, precentral gyrus, inferior parietal lobe and parietal and precuneus, right middle temporal gyrus, posterior cingulate and sea horse gyrus. (9) attention neutral face pictures, low testosterone level group of brain activation is uniformly left leaves under lateral nucleus. (10) attention neutral face pictures, a high degree of testosterone group growth than the low group activated brain areas are you on both sides of the postcentral gyrus and middle frontal gyrus, left paracentral lobule, precentral gyrus, superior temporal gyrus and the right fusiform gyrus, parietal and precuneus, superior frontal gyrus, cingulate and insula. (11) the left center of high degree of testosterone testosterone levels and pleasant emotional comfort group face activated frontal gyrus (r=0. 719), right cingulate gyrus (r=0. 719) intensity were positively related to emotional comfort, and terror face activation of the left insula (r=0. 638), right middle temporal gyrus (r=0. 855) intensity were positively related to. Conclusion: 1. Human emotion processing involves many brain cortex neural activation, processing of emotional brain differences titer both stack, and independence. Happy (positive) emotional face processing important touch the left hemisphere, terrorist (negative) emotional face processing your hemisphere are involved in. 2. High testosterone level of emotional face processing reach more brain regions, low testosterone level is on the contrary. 3. Testosterone levels and 2 pleasant brain regions (left precentral gyrus, right cingulate gyrus), 2 horror brain regions (left insula, right superior temporal gyrus) activation intensity were positively related to. ...
目录:封面1-2声明2-4目录4-6摘要6-8英文摘要8-10前言10-11对象／材料与方法11-18&&&&2．1 研究对象11-13&&&&2．2 情绪面孔刺激任务13-15&&&&2．3 成像设备与扫描参数15-15&&&&2．4 实验流程15-16&&&&2．5 数据分析16-18结果18-25&&&&3．1 行为学结果18-18&&&&3．2 fMRI数据分析结果18-24&&&&3．3 ROI分析24-25讨论25-33结论33-34参考文献34-39综述39-59附录59-66致谢66
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[1].郎彧珺. [D]. 大连医科大学.
2013[2].杨雨静. [D]. 首都师范大学.
2006[3].黄勤锦. [D]. 华南师范大学.热搜TAGS：
男，38岁。性欲减退、阳萎3年，近1年轻度头痛。头颅磁共振(MRl)检查发现高2.8cm垂体大腺瘤、压迫视神经交叉、浸润左侧海绵窦。第二天晨取血查垂体及其靶腺功能后接受了γ-刀垂体外照射放射治疗。5天后化验报告血睾酮水平0.7mmol／L、FSH及LH均<2mIU／L(垂体-性腺轴功能减低)，血PRL、GH、ACTH及TSH、T3、T4水平均无特殊。符合垂体无功能性大腺瘤。本例垂体腺瘤治疗
男，38岁。性欲减退、阳萎3年，近1年轻度头痛。头颅磁共振(MRl)检查发现高2.8cm垂体大腺瘤、压迫视神经交叉、浸润左侧海绵窦。第二天晨取血查垂体及其靶腺功能后接受了γ-刀垂体外照射放射治疗。5天后化验报告血睾酮水平0.7mmol／L、FSH及LH均<2mIU／L(垂体-性腺轴功能减低)，血PRL、GH、ACTH及TSH、T3、T4水平均无特殊。符合垂体无功能性大腺瘤。本例垂体腺瘤治疗
　　A．采用γ-刀放射治疗是合理的选择
　　B．用睾酮类药物替代治疗后再放射治疗
　　C．首选溴隐亭等多巴胺激动剂治疗
　　D．手术治疗、术后加用放射治疗
　　E．无功能性垂体腺瘤可暂不处理．观察1～2年
　　本题正确答案：B
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